Smartphone-based lab-on-a-chip immunosensors

2. 연사 : Jeong-Yeol Yoon, Ph.D., Associate Professor, Agricultural & Biosystems

            Engineering, The University of Arizona

3. 일시 : 2012년 6월 5일 (화) 16:30-17:30 p.m.

4. 장소 : 301동 305호

5. 내용 :

1. Assuring cell adhesion to an underlying biomaterial surface is vital in implant device design and tissue engineering, particularly under circumstances where cells are subjected to potential detachment from overriding fluid flow. In the present study we examined the effect on cell adhesion of combining: 1. optimized surface texturing, 2. electrostatic charge and 3. cell adhesive ligands, uniquely assembled on the substrata surface, as an ensemble of nanoparticles trapped in nanowells. Our results reveal that the ensemble strategy led to enhanced, more than simply additive, endothelial cell adhesion under flow. This strategy may be of particular utility for enhancing flow-resistant endothelialization of cardiovascular device blood-contacting surfaces subjected to flow-mediated shear.
> 2. A novel smartphone-based detection device was created in order to detect malaria antigens in human blood. iPhone 4's were used as a light source (flash) as well as a light detector (camera), which detected Mie scatter from the optofluidic channels. The detection limit was 1 pg/mL, about three orders of magnitude improvement over the other lab-on-a-chip detections of malaria antigens. This system requires no external power, is portable, and has an assay time of approximately 10 minutes.

6. 약력 : Jeong-Yeol Yoon received his B.S., M.S. and Ph.D. degrees in Chemical Engineering from Yonsei University, Seoul (South Korea) in 1992, 1994 and 1999, respectively, under the guidance of Professor Woo-Sik Kim, in collaboration with Professor Jung-Hyun Kim, where he worked primarily on polymer colloids. He received his second Ph.D. degree in Biomedical Engineering from University of California, Los Angeles in 2004, working on lab-on-a-chip and biomaterials, under the guidance of Professor Robin L. Garrell. He joined Department of Agricultural & Biosystems Engineering faculty in August 2004 and holds joint appointment in Department of Biomedical Engineering at The University of Arizona. He is also a faculty member of Biomedical Engineering Graduate Interdisciplinary Program (BME GIDP) and BIO5 Institute at The University of Arizona. Dr. Yoon is currently directing Biosensors Lab. He is a member of IBE, ASABE and SPIE, and was Councilor-at-Large for IBE for 2010 and 2011 calendar years. He currently serves as Associate Editor for Transactions of the ASABE (ASABE) and Biological Engineering Transactions (ASABE); Editorial Board Member for Journal of Biological Engineering (IBE), Resource Magazine (ASABE) and The Open Biotechnology Journal (Bentham).

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