3.  일시 : 2012년 12월 26일 (수) 오후 4시 30분

4.  장소 : 301동  1512-2호

5.  내용 : 

 In vivo, cells respond to surrounding mechanical/chemical stimulations and complex three-dimensional anisotropic environments. To understand these mechanisms, cells need to be maintained in an in vivo-like environment that reproduces key structural, functional, and mechanical properties of the target organ. In this talk, I will describe two biomimetic micro and nano systems that reconstitute critical functional aspects of the renal and nervous system. To study the complex morphogenetic event of neurite outgrowth, UV capillary force lithography process was used to construct different topographic patterns. These nanotopographical patterns can provide an insight into how neuronal growth cones can sense geometric ECM cues, which possibly leads to new applications in tissue regeneration after nerve injury as well as the treatment of neuropathological conditions. To emulate the kidney tubular environment, microfluidic-based techniques were used to recapitulate the complexity of the renal microenvironment in vitro. Culture of renal tubular cells in the microfluidic device under fluid shear stress resulted in enhanced cell polarization, cytoskeletal reorganization, and molecular transport. In addition, a human kidney proximal tubule-on-a-chip for more predictive in vitro human kidney models was developed for investigating absorption, distribution, metabolism, excretion, and toxicological properties of new chemical entities during the drug development process.  This novel system may also provide a useful and cost-effective tool for studying biotransformation profiles, pharmacology, drug transport and toxicity, and hence help to facilitate the drug development process with a more human-relevant model.

 

Doctor of Philosophy (March 2007 ~ August 2011)

 Interdisciplinary Program in Nano-science and Technology,Seoul National University

Bachelor of Science (March 1999 ~ February 2003)

 Department of Food and Nutrition, Hanyang University, Seoul, Korea

 

7. 문의: 기계항공공학부 서갑양 교수 (880-9103)

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